JOINT PRESS RELEASE
Frederick, MD, USA March 28, 2015 Sistemic Ltd. and RoosterBio Inc. announced today that they have entered into a commercial collaboration agreementand signed a memorandum of understanding whereby both companies will combine their technologies and work together towards advancing the field of mesenchymal stem/stromal cell (MSC) regenerative technology.
RoosterBio and Sistemic will collaborate on utilizing microRNA (miRNA)-based cell characterisation workflows and technologies to build more precise and relevant characterization panels for hMSC products and in process cell banks.
The collaboration furthers the identification of microRNA (miRNA) biomarkers across a wide range of donors predictive of hMSC performance based on a matrix of biological functions and outcomes of interest. Both companies envisage offering their customers’ access to the each other's technology platforms to enhance the quality, performance, and therapeutic knowledge of MSC technology. The eventual goal of the collaboration will be to erase the functional variability that is inherent in today’s MSC products and drive the evolution of stem cells from a science to a robust technology.
Since the initial identification and characterisation by Friedenstein and his colleagues, in 1974, the understanding of MSC biology, function and therapeutic applicability has gone a long way with hMSCs currently being the most commonly used stem cell type in clinical applications. To date, it has been shown that MSCs exist and can be isolated from almost every tissue, possess the ability to self-renew and differentiate into multiple lineages and exhibit immense therapeutic potential, with tissue regeneration, wound healing and immune system modulation capabilities as examples. Nevertheless, MSCs are also rare, prone to senescence upon extended culture, exhibit variable potency and show wide donor to donor variability. Both RoosterBio and Sistemic recognise the significance of these challenges and are fully committed to developing solutions that will enable the full therapeutic potential and wide spread commercial use of MSC technology.
Dr Daria Olijnyk, Senior Scientist and Business Development Associate of Sistemic said “Sistemic as a leading provider of miRNA-based tools for cell characterisation and quality control of cell therapy products has a significant interest in and a detailed understanding of the field of MSC characterisation and is fully committed to utilizing its expertise to provide innovative solutions to accelerate and optimise the clinical translation and cost-effective use of MSCs. We are very excited to announce our collaborative partnership with RoosterBio. We believe that with both companies working towards a common goal and combining our complementary expertise we will accelerate the development of a range of well characterised, easily scalable and highly potent MSC products which can be pre-selected based on their intended application. Combining Sistemic’s informatics capabilities and extensive knowledge base on existing MSCs allows both companies to combine their strengths to understand and potentially overcome donor-to-donor variability which has been a significant industry challenge, up to this point in time.”
Jon Rowley of RoosterBio, said “Collaborating with Sistemic is an example of a true “1+1 = 3” scenario. Thorough characterization of hMSC products and cell banks is central to crating a stable, robust technology that can be simply and affordably deployed across a range of applications – from cell therapies to 3D bioprinting. RoosterBio’s rich library of MSC donors married with Sistemic’s miRNA characterization platform will provide both predictive biomarkers and critical quality attributes that will allow MSC technology to reach its full potential, sooner. This collaboration will not only advance the science of stem cells, but accelerate the clinical and commercial translation of this technology.”
The collaboration, while organic in nature, is also being driven by commercial interest and an, as yet, underserved market need. Both Sistemic and RoosterBio have respectively served their customers seeking greater MSC characterization, and will now do so with a unified effort. The collaboration will endeavour to accelerate the development and commercial potential of Regenerative Medicine products.
Sistemic’s primary business is focused on providing innovative microRNA-based problem-solving services and kit-based products to areas of unmet need within Pharmaceutical, Biotechnology and the Cell Therapy research, development and manufacture markets. MicroRNAs are seen as the master controllers of a cell and as such Sistemic believe that they are providing instructive information on effects on a whole cell or organism rather than an isolated pathway. This system approach means that the data produced is more indicative of the biology and more diagnostic of actual effect. Their extensive suite of tools for the Cell Therapy community includes SistemQC™ which is used to characterise cells including stem cells (Cell Identity, Purity, Potency, and Safety) as well as monitoring the QC of production. Furthermore, cell products in the later stages of clinical development benefit from SistemQC™ miRNA-based profiling approach in facilitating patient stratification and monitoring the response to the treatment. In addition, the drug development markets are served through a range of products which include SistemTOX™ , SistemKB™ and SistemRNA™ . Sistemic has a worldwide customer base and a strong intellectual property portfolio.
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RoosterBio is a privately held biofabrication technology and products company focused on accelerating the development of a sustainable regenerative medicine industry, one customer at a time. RoosterBio’s products are high volume, affordable, and well-characterized adult human mesenchymal stem/stromal cells (hMSCs) paired with highly engineered media systems. RoosterBio has simplified and standardized how stem cells are purchased, expanded, and used in development, leading to marked time and costs savings for customers. RoosterBio’s innovative products are ushering in a new era of productivity and standardization into the field, where researchers spend newly found time and money performing more high-value experiments, accelerating the road to discovery in Regenerative Medicine. For more information on RoosterBio and adult stem cells, you can visit www.roosterbio.com, follow on twitter (@RoosterBio), or read the blog “Democratizing Cell Technologies” (www.roosterbio.blogspot.com).
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